NUCLEOFILL STRONG PLUS (1x2ml)
In the realm of high-end aesthetic medicine, where patients demand results that merge nature with science, Nucleofill Strong Plus sets new standards for modern bioregeneration. This is not just another dermal filler – it is an advanced medical instrument that programs the skin for deep restructuring, restoring its original density and youthful vigor. As a flagship solution in the Aesthetic Pharma portfolio, this preparation allows practitioners to offer a non-surgical face lift, based on the biological rebirth of tissues.
MECHANISM OF ACTION – INTELLIGENT BIOSTIMULATION
The efficacy of Nucleofill Strong Plus relies on a unique, triple-action pathway that goes beyond classic skin boosters:
- Receptor Biostimulation: Polynucleotides injection activates CD39 and CD40 receptors on fibroblasts, forcing the production of type I collagen and elastin. This process induces the transformation of fibroblasts into myofibroblasts, resulting in real, visible skin tightening.
- Antioxidant Action: Polymeric macromolecules act as free radical scavengers, protecting cellular DNA from damage and inhibiting photoaging processes.
- Iso-osmotic Hydration: Thanks to strong hydrophilic properties, the preparation binds water in the extracellular matrix, ensuring deep tissue bio-restructuring and long-lasting hydration.
What distinguishes the Strong Plus version is the record concentration of polynucleotides (25 mg/ml) and increased volume – a full 2ml, making it the ideal choice as a skin booster for neck and décolletage laxity as well as the entire face in one session. In professional debates regarding Nucleofill vs Profhilo, the Promoitalia product is highlighted as a solution with stronger regenerative potential for mature skin requiring structural repair rather than just hydration.
INDICATIONS
- Advanced signs of aging and loss of skin density,
- Tissue laxity (jowls effect, lost facial contour),
- Dehydrated, dull skin lacking radiance,
- Deep folds and wrinkles requiring anti-aging biorevitalisation,
- Scar and stretch mark therapy, and skin regeneration after invasive procedures.
COMPOSITION
Active ingredient: Polynucleotides (PDRN) at a concentration of 25 mg/ml (2.5%)
Physicochemical parameters: pH 6.8–7.5, high viscosity (48–65 Pa*s)
Lidocaine: -
TREATMENT METHOD AND PROTOCOL
Nucleofill Strong Plus is characterized by excellent rheology, allowing for precise work with various injection techniques:
- 5-Point Technique (BAP): Optimal for lifting the mid and lower face, minimizing patient discomfort.
- Linear/Retrograde Technique: Using a cannula (25G-27G) for broad biostimulation of large areas (neck, cheeks).
- Multi-injection Technique: Classic intradermal administration for intensive hydration.
The standard protocol includes a series of 4 treatments at intervals of 2-4 weeks. The effect lasts up to 12 months, ensuring patients natural rejuvenation without the risk of artificial volume.
PACKAGING
1 pre-filled syringe with 2 ml of preparation
2 sterile needles 30G 1/2"
CONTRAINDICATIONS
- Hypersensitivity to polynucleotides (salmon derivatives),
- Pregnancy and breastfeeding,
- Active skin infections (bacterial, viral),
- Active cancer and autoimmune diseases.
MANUFACTURER
Promoitalia Medical Aesthetics (Italy) – A pioneer and global leader in the field of polynucleotide biostimulation, delivering solutions based on the highest pharmaceutical purity and years of clinical research.
Product for professional use only. Aesthetic Pharma supplies only authentic preparations directly from verified distribution channels, guaranteeing their originality and highest biological purity.
Please read the package leaflet before use.
Comprehensive Regenerative Therapy
For optimal results in total facial aesthetics, Aesthetic Pharma specialists recommend synergy with other variants of the Nucleofill line:
- Prevention and early signs of aging: Choose Nucleofill Medium – ideal for younger skin and prophylactic actions.
- For the delicate eye area: Use Nucleofill Soft Plus Eyes – a precise biostimulator reducing dark circles and eyelid laxity.
By choosing original products at Aesthetic Pharma, you invest in the authority of your clinic and the safety of your patients.
FREQUENTLY ASKED QUESTIONS (FAQ) – AESTHETIC PHARMA EXPERT ANSWERS
1. What is the fundamental difference between Nucleofill Strong and Nucleofill Strong Plus?
Nucleofill Strong Plus (formerly known as Nucleofill Age) is the evolution of the classic Strong version. Both preparations offer the highest concentration of polynucleotides (25 mg/ml), but the Strong Plus version contains 2 ml of product (instead of 1.5 ml). For the practitioner, this means 33% more product, allowing for full treatment of the face and neck or the use of more intensive injection techniques with a single syringe.
2. Nucleofill vs Profhilo – which preparation is better for a patient with significant skin laxity?
The choice depends on tissue condition. Profhilo, based on hyaluronic acid, moisturizes excellently and gives a "glow" effect. However, for patients 50+ with a clear density deficit and sagging oval, Nucleofill Strong Plus is often the superior choice. Thanks to polynucleotides, it acts at the receptor level, forcing the skin to actually produce type I collagen, resulting in a more durable structural lifting effect, not just volumetric.
3. Can Nucleofill Strong Plus cause allergic reactions?
The preparation is characterized by the highest safety profile and full biocompatibility with human tissues. The active ingredient – Salmon DNA – is 97% compatible with the human genetic code. The only rare contraindication is a confirmed allergy to fish proteins. The product is free from chemicals with high allergenic potential.
4. What are the most common side effects and how long is the recovery?
The procedure is minimally invasive. Immediately after injection, typical symptoms may occur: slight swelling, redness, or minor bruising at injection points. Thanks to the 5-point technique (BAP) or cannula use, these symptoms usually subside within 24–48 hours, allowing the patient a quick return to daily activities.
5. Is the lifting effect visible immediately after leaving the clinic?
Nucleofill works in two stages. The first effect – slight tension and hydration – results from the iso-osmotic properties of the gel and is visible almost immediately. However, for the target cellular level lifting, one must wait 2 to 4 weeks. This is the time fibroblasts need to synthesize new protein fibers. Full regeneration and tissue remodeling occur after a series of treatments.
6. Why is it worth introducing Nucleofill Strong Plus 2ml to a premium clinic offer?
From the perspective of profitability and clinic prestige, the 1x2ml version is unrivaled. It allows for the implementation of a holistic treatment protocol (face + neck) while maintaining the highest standard of medical purity. Premium segment patients value Nucleofill for natural anti-aging results without the "overfilled" face effect, which builds loyalty and trust in the doctor's competence.
