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Nucleofill Medium (1x1,5ml)

$32.09 Save 50%
Lowest price within 30 days before promotion: $45.62





Short expiration date: 03/2024

Polynucleotides | Medical Device

For oxygen-deprived and dehydrated skin | Improves skin elasticity and density | Smoothing of moderately deep wrinkles | Treatment of moderate scars and stretch marks

Application areas: Face | Neck | Décolleté | Hands | Thighs | Buttocks



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Linerase Collagen


Nucleofill for Biostimulation - Regeneration - Skin Densification - Lifting.

This is a new and innovative product line from the esteemed Italian company Promoitalia for biostimulation based on natural polynucleotides. Polynucleotides are naturally occurring polymers of nucleotides, including:

  • compounds building nucleic acids - DNA and RNA,
  • compounds building cofactors and coenzymes, including the respiratory pathway.

Polynucleotides activate 2 types of membrane receptors on fibroblasts, thereby contributing to the stimulation of collagen type I production and the maturation of fibroblasts into myofibroblasts.

Nucleofill also contributes to "binding free radicals" through polymeric macromolecules that act immediately.

Thanks to the binding of water by the hydrophilic groups of individual nucleotides, deep hydration of tissues and the extracellular matrix occurs.

Nucleofill Medium should not be used for injections in the peri-orbital area (eyelids, eye socket). Nucleofill should only be administered subcutaneously or intradermally. Do not administer intravascularly.

The lack of proteins and sugars in the product makes it safe.

The product can be used in the treatment of various body parts: neck, décolleté, face (cheeks, cheekbones), dorsal surface of hands, abdominal cavity, thighs, and buttocks.

Best results are achieved after 2-4 treatments performed at intervals of 14 - 30 days. This session can be repeated from one to three times a year.

Administration Techniques
  • 5-point technique,
  • linear technique,
  • multi-injection technique.


The treatment can be performed regardless of age and skin type.

  • oxygen-deprived and dehydrated skin,
  • restoration of tissue elasticity,
  • improvement of skin density,
  • treatment of medium-depth wrinkles, superficial wrinkles around the mouth and on the cheeks,
  • treatment of medium scars and stretch marks.


  • gel with a 2% concentration of Polynucleotides,
  • pH between 6.8 - 7.2,
  • viscosity: 28 - 43 PA*S.


1 ampoule-syringe with 1.5 ml of the preparation

2 needles 30G 13mm


  • circulatory diseases,
  • persistent inflammatory skin conditions,
  • epilepsy,
  • diabetes,
  • herpes,
  • past or present autoimmune diseases,
  • pregnancy and breastfeeding,
  • not to be used in individuals under 18 years of age,
  • antibiotic therapy.


The procedure should be performed by a specialist familiar with the administration method.

The recommended injection technique depends on the type of wrinkles, individual patient needs, skin condition, and expected results. Nucleofill can be administered using various injection techniques: linear, point, cross-linked, fan. Massage the treated area after injection to ensure proper product distribution.

Before the procedure, patients should be informed about the composition of the preparation, its properties, possible side effects, and risks. The treatment area should be thoroughly disinfected. The product should be injected slowly into the skin.

After the procedure, there may be slight swelling, redness, or minor bruising, which disappears within a few hours to several days.


Store at a temperature between 5 to 25°C. Protect from sunlight and freezing. Do not freeze. Keep out of reach of children.



Product for use only by professionals. By choosing to purchase, you declare that you are a trained doctor or cosmetologist in the field of aesthetic medicine.

Before use, familiarize yourself with the contents of the leaflet included in the packaging.

Specific References



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